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KMID : 1094020160330050255
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Journal of Veterinary Clinics
2016 Volume.33 No. 5 p.255 ~ p.260
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Evaluation of Pyunkang-tang® Administration on Hematological, Biochemical, and Protein and Lipid Profiles in Dogs
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Park Won-Keun
Park Sung-Jae
Kim Seung-Gon
Kang Min-Hee
Park Hee-Myung
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Abstract
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Pyunkang-tang® is a kind of herbal medicine and has been used for the treatment of atopy and allergicdisease in humans over forty years. The purpose of this study was to evaluate the hematological, biochemical, andprotein and lipid electrophoresis profiles after the oral administration of Pyunkang-tang® in healthy dogs. Fifteenclinically healthy beagle dogs were selected and orally administered either 33 ml of Pyunkang-tang® (group I, n = 5),16.5 ml of Pyunkang-tang® (group II, n = 5), or 33 ml of distilled water (group III, n = 5) 3 times a day for 4 weeks. The results of the hematological, serum biochemical, and urine analysis did not differ significantly among the 3 groups. The oral administration of Pyunkang-tang® for 4 weeks was associated with significant changes in the serum globulinlevels and an elevation in the high-density lipoprotein (HDL) concentrations in groups I and II (p < 0.05), comparedto group III. The α1-globulin and γ-globulin levels were significantly increased in group I, and the α1-globulin andβ-globulin levels were significantly increased in group II. The α2-globulin levels were significantly decreased in bothgroups. During the short-term evaluation of Pyunkang-tang® administration, we did not detect any specific adverseeffects in the dogs. However, further evaluation of the safety and efficacy of Pyunkang-tang® for the treatment ofatopic disease in dogs is needed.
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KEYWORD
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lipoprotein electrophoresis, Pyunkang-tang®, safety, serum protein electrophoresis
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